A large-scale study of two million vaccinated people has uncovered evidence that Covid mRNA shots trigger psychiatric adverse events.
The peer-reviewed study was conducted by top Korean scientists and published in the world-renowned Nature Journal.
Led by Eun Mi Chu from the School of Medicine Ewha Womans University in Seoul, South Korea, the team of researchers analyzed the data of two million Korean citizens who had received at least one dose of a Covid mRNA shot.
The study looked into serious adverse events (AEs) of a psychiatric nature linked to COVID-19 vaccination.
The researchers noted that, while evidence associated with an increased risk of psychiatric manifestations does exist after viral infections including COVID-19, such incidence–psychiatric adverse events (AEs) post COVID-19 vaccination as documented in various studies and reports is less clear.
Enter this study, an investigation probing for psychiatric AEs after COVID-19 vaccination from a large population-based cohort in Seoul, South Korea.
The researchers employed statistical tools such as hazard ratios in a population of over 2 million Koreans to determine COVID-19 vaccination is associated with several psychiatric events.
This is an observational study not designed to prove causation.
The team used real-world official government data in the Korean National Health Insurance Service (KNHIS) claims database starting January 1, 2021.
The study investigators recruited 50% of this Seoul-resident population randomly selected.
The vast majority of Korean adults were vaccinated against COVID-19.
Multiple vaccines were used in Korea with the majority of doses being represented by the Pfizer-BioNTech mRNA vaccine.
The study population included a total of 2,027,353 participants from the KNHIS claims database.
They were divided into two groups according to COVID-19 vaccination.
Mi Chun and co-authors assessed the cumulative incidences per 10,000 of psychiatric AEs in one week, two weeks, one month, and three months post-COVID-19 vaccination.
The authors measured hazard ratios (HRs) and 95% Confidence interval (Cis) of psychiatric AEs for the vaccinated population.
Importantly, the South Korean investigators report the “cumulative incidence of depression, anxiety, dissociative, stress-related, and somatoform disorders, sleep disorders, and sexual disorders at three months following COVID-19 vaccination were higher in the vaccination group than no vaccination group.”
The serious conditions of “schizophrenia and bipolar disorders showed lower cumulative incidence in the vaccination group than in the non-vaccinated group.”
The authors report, “Depression (HR [95% CI] = 1.683 [1.520–1.863]), anxiety, dissociative, stress-related, and somatoform disorders (HR [95% CI] = 1.439 [1.322–1.568]), and sleep disorders (HR [95% CI] = 1.934 [1.738–2.152]) showed increased risks after COVID-19 vaccination, whereas the risks of schizophrenia (HR [95% CI] = 0.231 [0.164–0.326]) and bipolar disorder (HR [95% CI] = 0.672 [0.470–0.962]).”
The outcomes of this study reveal:
“COVID-19 vaccination increased the risks of depression, anxiety, dissociative, stress-related, and somatoform disorders, and sleep disorders while reducing the risk of schizophrenia and bipolar disorder.”
The authors suggest providers be cognizant to proceed with caution when vaccinating vulnerable people vulnerable to psychiatric AEs.
The authors conclude with an alarming statement:
“Our findings suggested that the relationship between COVID-19 vaccination and mental illness may be underestimated along with the complexity of its impact on mental health.
“Thus, close observation and special caution are necessary for administering additional COVID-19 vaccinations to populations vulnerable to psychiatric AE.”
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